The history of Aesculapius is reconstructed through the collection of legends and myths created by Greek paganism. Their religion was polytheistic, with a multitude of divinities and demigods associated with all aspects of human life and with several especially sacred places, such as some rivers and fountains, mountains and forests. This multitude of gods was subordinate to a group of powerful principal deities, most of whom, according to them, lived on Mount Olympus, and these in turn were chaired by Zeus. Among the main gods was Apollo, son of Zeus, god of the sun, light, music and arts, prophecy and healing, patron of the young, of the lecture and conductor of the muses, who was, according to some versions of the myth, Esculapius's father.
The oldest record of his name is found in Homer's Iliad, and in that quote he was apparently still considered a mortal, described as the ruler of Tricca and also as a doctor who had learned the art of the Chiron centaur and taught it to his two sons, Podalírio and Macaão. Since the Homeric account of the Trojan War is now considered the poetization of a possibly historic event, Aesculapius may have actually existed, living around 1200 B.C., and was later deified. In Greek culture, it was common for famous heroes to be the object of worship after their death.
Writing in the first century, he explained that because he perfected the medical arts, formerly primitive, he deserved a place among immortals. The origins of its name are obscure. It is possible that it meant "gentle healer", it was also reported that at first he was called Epios, and that after curing Ascles, tyrant of Epidaurus, he was renamed Asclepios. His divine status was not unanimous among the ancients, some regarded him as a god, others as a hero-god or as a demigod. By the 5th century BC, there was already a great deal of folklore created about him, and Píndaro wrote saying that he was the son of Apollo with the mortal Coronis, daughter of Phlegias, the ruler of Thessaly. The place of his birth was disputed by several cities: Lacereia, Tricca and Epidauro.