Years after Titanomachy, King Hiperyon (Mickey Rourke) declares war on the gods. He seeks out the Arch of Epirus, a legendary weapon created by the underworld god Hades, which will allow him to free the Titans from Tartarus and take revenge on the Olympic gods. According to ancient laws, the gods are unable to intervene in the war between Hyperion and humanity. Then a peasant named Theseus (Henry Cavill) is chosen by Zeus (Luke Evans) and, accompanied by the priestess Phaedra (Freida Pinto) and a slave (Stephen Dorff), leads the men to try to protect their homeland and prevent the liberation of the titans.